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Brain Defenders

How to Protect Your Brain for Life

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Brain Defenders

By: David Perlmutter
Narrated by: Peter Ganim
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'A science-based, actionable blueprint to shift the brain from decline to repair.' ― Dr David Sinclair, New York Times bestselling author of Lifespan

A ground-breaking new book from the bestselling author Dr David Perlmutter that will transform our understanding and treatment of degenerative brain diseases.

In recent years microglia cells housed in the brain have been identified as playing a key role in a host of neurodegenerative diseases such as Alzheimer's, Parkinson's, Long Covid, and MS amongst others. When operating optimally, these cells support healthy brain function. However, when they go rogue, they cause inflammation in the brain, contributing to cell death and devastating neurological conditions.

Current drug treatments mostly mask symptoms rather than cure and the statistics are grim: worldwide, 55 million people suffer from Alzheimer's, 10 million people have been diagnosed with Parkinson's, and serious neurological disorders are on a rapid rise.

And the good news? By following the lifestyle protocol that Dr David Perlmutter presents in the book people can become 'architects of their cognitive destiny'. The Brain Defenders program is accessible to all and will help us start to win the war against the scourge of neurodegenerative diseases.©2026 David Perlmutter, M.D. (P)2026 Penguin Random House Audio
Brain & Nervous System Physical Illness & Disease
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Critic reviews

A science-based, actionable blueprint to shift the brain from decline to repair.
David Perlmutter consistently has his finger on the pulse of the newest and most important brain health research.
Brain Defenders offers a powerful roadmap grounded in rigorous science and practical application.
Brain Defenders is a landmark work that puts the power of prevention in your hands.
This book is a must read for anyone seeking a roadmap on how to shore up your brain's resilience against diseases of aging.
This book is an essential resource for clinicians and informed patients who want to shift from crisis response mode to proactive brain stewardship.
Brain Defenders is an essential read for anyone seeking to enhance mental clarity, longevity, and overall brain wellness.
Brain Defenders offers a clear, accessible look at how metabolism, inflammation, and immune function influence brain health.
Brain Defenders reveals the breakthrough biology driving today's brain health crisis-and why this research is our best shot for the future of brain health.
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