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Episode description

In Part 2, Yulia Mintchin gets practical — covering what women should actually do at every stage, the FemGene patient journey, her own health transformation on HRT at 31, and a surprising conversation about art, creativity and feminine power as the next frontier in women’s health

Key topics discussed

• Top three interventions for women aged 30–45
• When to start genetic testing, with Yulia’s view being post-puberty
• Cyclical nutrition: why carbs in the luteal phase support progesterone
• Why cryotherapy and cold exposure can backfire depending on genetic stress response
• Medical curriculum gaps: why perimenopause does not belong in sick care
• The gold standard perimenopause visit in 2030
• Will Be’s pharmacogenomic platform vision
• Insurance models and the economics of preventative medicine
• FemGene patient journey: telemedicine, test kits, Dr Vanessa consultation
• Can oestrogen receptors reactivate post-menopause? Emerging research
• Optimal hormones as a foundational baseline, not a longevity bonus
• Peptides: only stack after hormonal foundations are in place
• Yulia’s personal story: health crisis at 31, HRT and the endometriosis link
• Keto, sourdough and changing her mind on carbs
• The digital twin: which data streams matter and which are just noise
• Curveball: the billboard question — rewriting behaviour patterns through art
• Remember Who You Are — Yulia’s musical
• Joseph Campbell, the hero’s journey and stories as healing
• Spiral dynamics and collective consciousness
• A Russian utopian book by a female author written during the USSR period
• Peptides for mitochondria as a sub-$1,000 purchase recommendation
• Piano as an introvert’s creative practice
• Biohacking Eve episode on EMS (Episode 3)

Timestamps

00:00 Why Part 2 is the action plan
01:00 Top interventions before HRT
02:20 Keto, carbs and cyclical eating
07:00 What a gold standard perimenopause visit should look like
09:30 Insurance, self-pay and democratising access
13:20 The research questions FemGene wants to answer
18:10 Why Yulia started HRT at 31
23:10 “It’s not too early” for hormone optimisation
25:00 Female digital twins and meaningful data
27:10 Why optimal hormones are a baseline, not a luxury
30:40 Why fasting and cryo are not for everyone
33:35 One change healthcare professionals can make now
35:50 Art, feminine energy and women’s health
44:30 The spiritual experiences behind Yulia’s mission
49:45 Peptides, piano and personal rituals
53:40 What comes next for Will Be and FemGene

References and resources mentioned

• FemGene hormone genomic test — via Will Be: https://www.mywillbe.co.uk/
• Joseph Campbell — The Hero with a Thousand Faces
• Spiral dynamics — developmental model of collective consciousness
• Biohacking Eve episode on EMS / strength training, referenced as approximately Episode 3
• A Russian utopian book by a female author, written during the USSR period
• Remember Who You Are — musical by Yulia Mintchin
• Health Optimisation Summit, London
• Dr Vanessa — chief scientist at Will Be

Guest social links

• &n

Insta/TikTok: @BiohackingEve
Website: www.BiohackingEve.com

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Episode description

Yulia Mintchin, Forbes 30 Under 30 entrepreneur and creator of FemGene, reveals why perimenopause is an epigenetic reprogramming event — not just a hormone dip — and how genetic testing can predict your symptoms and HRT response before a single prescription is written

Key topics discussed

• Perimenopause as a communication breakdown between genes and hormones
• Why women were excluded from medical research and what that means today
• Hormone genomics and hormone genetics — a new medical category
• The three hormonal archetypes: Sensitive, Silent and Resilient
• The COMT gene variant and oestrogen clearance, affecting around 20% of the population
• Why HRT fails for 40% of women — and how FemGene aims to fix that
• Hormone metabolites vs hormone levels: the missing safety step
• Bioidentical vs synthetic oestrogen — the cherry Haribo analogy
• Endometriosis case study: progesterone and halted progression
• Oncology’s shifting stance on HRT and oestrogen during cancer treatment
• The WHI study and tamoxifen: historical context

Timestamps

00:00 Why perimenopause may be about genetic response, not just hormone decline
01:00 Meet Yulia Mintchin and the FemGene thesis
03:10 Why perimenopause is medicine’s biggest blind spot
05:05 Hormone genomics and hormone genetics explained
14:15 The three hormonal archetypes: Sensitive, Silent and Resilient
23:05 Why doubling HRT doses can backfire
24:10 COMT, oestrogen clearance and personalisation
31:40 When women should start testing
33:20 Endometriosis case study: progesterone and progression
37:20 How archetypes change HRT decisions
41:05 What the FemGene process looks like
45:00 Bioidentical vs synthetic oestrogen
51:20 Red flags that HRT is being managed poorly
56:05 Oncology, HRT and shifting views on oestrogen
58:10 Outro and disclaimer

References and resources mentioned

• FemGene hormone genomic test — via Will Be: https://www.mywillbe.co.uk/
  
  
• The WHI (Women’s Health Initiative) study — landmark trial that shaped HRT policy
• Biohacking Eve episode with Jennifer Garrison, referenced as approximately Episode 1, on hormonal changes affecting 80% of body systems
• COMT gene and oestrogen metabolism — widely studied SNP; Yulia references the slow COMT variant
• Tamoxifen and breast cancer treatment — historical context discussed

Guest social links

• Instagram: https://www.instagram.com/yulia.mintchin/
• LinkedIn: https://www.linkedin.com/in/yuliamintchin/
• Will Be website: https://www.mywillbe.co.uk/

Insta/TikTok: @BiohackingEve
Website: www.BiohackingEve.com

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A Neuroscientific Approach to Menstrual Wellness with Dr Emile Radyte: Exploring Brain-Based Pain and Mood Therapies

In this episode, we welcome Dr Emile Radyte, a Harvard and Oxford-trained neuroscientist specialising in how the brain influences menstrual mood and pain

Dr Radyte discusses her extensive background, including her leadership at Harvard’s emergency medical service and the founding of Lithuania’s largest neuroscience NGO. She is the co-founder of a neuroscience company focused on a brain-first approach to menstrual wellness. The conversation dives deep into the neuroscience behind menstrual pain and mood, explaining how brain circuits, rather than just hormones, regulate these experiences

Dr Radyte elaborates on the innovative non-invasive brain stimulation techniques her team is developing to provide pain relief and mood stabilisation for women with conditions such as PMS, PMDD and endometriosis. She also shares insights on the interplay between hormones, neuroplasticity and brain circuits, as well as ongoing clinical trials and the personalisation of therapeutic protocols for different conditions

Throughout the episode, she highlights the crucial role of self-tracking and personal responsibility in women’s health optimisation

Timestamp

00:00 Introduction and guest welcome
01:05 Understanding the brain-first approach to menstrual health
02:57 Brain circuits and emotional regulation
06:54 Pain perception and sensitivity
09:19 PMS vs PMDD: clinical definitions and differences
12:54 Brain stimulation: a new approach to menstrual health
29:14 Devices and technology for menstrual wellness
35:50 Understanding women’s symptoms and tracking
37:32 Common user mistakes and how to avoid them
41:06 Clinical trials and research initiatives
50:33 User experience with the devices
01:00:43 Curveball questions and personal insights

Resources Mentioned in This Episode

1. Samphire Neurotechnology

• Samphire is a neurotechnology company focused on women’s brain health, particularly hormonal-cycle related symptoms such as:
  • PMS
  • PMDD
  • Menstrual migraines
  • Brain fog
  • Mood and cognitive disruption linked to hormonal changes
• The technology discussed is non-invasive neuromodulation, designed as a drug-free alternative for managing symptoms.

2. Neuroscience & Hormonal Health

• Discussion around how hormonal fluctuations impact the brain, not just reproductive organs.
• Emphasis on the lack of research funding and innovation in women’s neurological health.
• The gap between male-centric medical research models and women’s lived neurological experiences.
  
  

3. Clinical & Regulatory Context

• Samphire’s work within regulated medical frameworks.
• Importance of clinical validation, safety, and evidence-based design for women’s health technology.
• Barriers women face accessing care for cycle-linked neurological symptoms.

4. Lived Experience & Advocacy

• Emile shares the personal motivation behind building Samphire.
• Reframing “normal” suffering around periods and hormones.
• Advocating for women to expect better solutions, not just coping strategies.
  
  
  

Social Media Links

Samphire Website: https://url-shortener.me/4QQW
LinkedIn:https://www.linkedin.com/in/eradyte/

Instagram:https://www.instagram.com/radytee/?hl=

Insta/TikTok: @BiohackingEve
Website: www.BiohackingEve.com