Drs Ursula A. Matulonis and Stephanie Lheureux discuss the importance of investigator-initiated clinical trials in endometrial cancer, research on carcinosarcoma, and ctDNA.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/ca8/p04/podcast-endometrial-cancer-s3-ep4-2026a10006ie. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Endometrial Carcinoma https://emedicine.medscape.com/article/254083-overview

Advances in Antibody-Drug Conjugates for Endometrial Cancer https://pubmed.ncbi.nlm.nih.gov/40111079/

TCGA Molecular Prognostic Groups of Endometrial Carcinoma: Current Knowledge and Future Perspectives https://pubmed.ncbi.nlm.nih.gov/36232987/

Translational Randomized Phase II Trial of Cabozantinib in Combination With Nivolumab in Advanced, Recurrent, or Metastatic Endometrial Cancer https://pubmed.ncbi.nlm.nih.gov/35288469/

Elucidating Divergent Biology in Uterine Carcinosarcoma https://pubmed.ncbi.nlm.nih.gov/40850250/

The Immune Microenvironment in Endometrial Carcinoma: Mechanisms and Therapeutic Targeting https://pubmed.ncbi.nlm.nih.gov/40746533/

Epithelial-Mesenchymal Transition Orchestrates Tumor Microenvironment: Current Perceptions and Challenges https://pubmed.ncbi.nlm.nih.gov/40176117/

Comparative Modeling of Recent and Projected Trends in the Incidence and Mortality of Uterine Cancer https://pubmed.ncbi.nlm.nih.gov/41643197/

Genomic Landscape of ctDNA and Real-World Outcomes in Advanced Endometrial Cancer https://pubmed.ncbi.nlm.nih.gov/39417689/

Targeting CDK2 for Cancer Therapy https://pubmed.ncbi.nlm.nih.gov/40802510/

PYNNACLE Phase II Trial Assessing Rezatapopt (PC14586), a Selective p53 Reactivator, in Patients With Locally Advanced or Metastatic Solid Tumors Harboring a TP53 Y220C Mutation https://www.gynecologiconcology-online.net/article/S0090-8258%2825%2900347-6/abstract

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Drs Ursula Matulonis and Jessica St. Laurent discuss endometrial cancer research, funding, early detection, and treatment, including the impact of GLP-1 receptor agonists.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/ca8/p04/podcast-endometrial-cancer-s3-ep3-2026a10006id. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Endometrial Carcinoma https://emedicine.medscape.com/article/254083-overview

Hereditary Breast and Ovarian Cancer (HBOC): Review of Its Molecular Characteristics, Screening, Treatment, and Prognosis https://pubmed.ncbi.nlm.nih.gov/32862296/

Shifted Assembly and Function of mSWI/SNF Family Subcomplexes Underlie Targetable Dependencies in Dedifferentiated Endometrial Carcinomas https://pubmed.ncbi.nlm.nih.gov/41116019/

Cancer Statistics, 2026 https://pubmed.ncbi.nlm.nih.gov/41528114/

Tirzepatide as an Innovative Treatment Strategy in a Pre-Clinical Model of Obesity-Driven Endometrial Cancer https://pubmed.ncbi.nlm.nih.gov/39388742/

Glucagon-Like Peptide 1 Receptor Agonists and 13 Obesity-Associated Cancers in Patients With Type 2 Diabetes https://pubmed.ncbi.nlm.nih.gov/38967919/

GLP-1 Receptor Agonists Plus Progestins and Endometrial Cancer Risk in Nonmalignant Uterine Diseases https://pubmed.ncbi.nlm.nih.gov/41665904/

TCGA Molecular Prognostic Groups of Endometrial Carcinoma: Current Knowledge and Future Perspectives https://pubmed.ncbi.nlm.nih.gov/36232987/

Menstrual Cup for Early Endometrial Cancer Detection in Lynch Syndrome (SCREEN-CUP) https://clinicaltrials.gov/study/NCT07220239

Circulating Tumor DNA in Endometrial Cancer: Clinical Significance and Implications https://pubmed.ncbi.nlm.nih.gov/39955181/

PTEN Mutations as Predictive Marker for the High-Grade Endometrial Cancer Development in Slovak Women https://pubmed.ncbi.nlm.nih.gov/36592448/

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Drs Ursula A. Matulonis and David G. Mutch discuss past and present endometrial cancer research, including the Route 66 SPORE.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/ca8/p04/podcast-endometrial-cancer-s3-ep2-2026a10006ic. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Endometrial Carcinoma https://emedicine.medscape.com/article/254083-overview

Route 66 Endometrial Cancer SPORE https://dctd.cancer.gov/research/spores/state/wustl-endometrial

Final Analysis of RTOG 9708: Adjuvant Postoperative Irradiation Combined With Cisplatin/Paclitaxel Chemotherapy Following Surgery for Patients With High-Risk Endometrial Cancer https://pubmed.ncbi.nlm.nih.gov/16545437/

Pelvic Radiation With Concurrent Chemotherapy Compared With Pelvic and Para-Aortic Radiation for High-Risk Cervical Cancer https://pubmed.ncbi.nlm.nih.gov/10202164/

Surgical-Pathological Findings in Type 1 and 2 Endometrial Cancer: An NRG Oncology/Gynecologic Oncology Group Study on GOG-210 Protocol https://pubmed.ncbi.nlm.nih.gov/28392124/

GOG Foundation https://www.gog.org/

The Latest Updates in Translational Science at NRG Oncology (October 2025) https://www.nrgoncology.org/Home/News/Post/the-latest-updates-in-translational-science-at-nrg-oncology-october-2025/

Adjuvant Chemotherapy Plus Radiation for Locally Advanced Endometrial Cancer https://pubmed.ncbi.nlm.nih.gov/31189035/

Adjuvant Chemoradiotherapy Versus Radiotherapy Alone in Women With High-Risk Endometrial Cancer (PORTEC-3): 10-Year Clinical Outcomes and Post-Hoc Analysis by Molecular Classification From a Randomised Phase 3 Trial https://pubmed.ncbi.nlm.nih.gov/40921169/

FIGO Staging of Endometrial Cancer: 2023 https://pubmed.ncbi.nlm.nih.gov/37337978/

Practical Guidance for Assessing and Reporting Lymphovascular Space Invasion (LVSI) in Endometrial Carcinoma https://pubmed.ncbi.nlm.nih.gov/38937066/

Surgical Pathologic Spread Patterns of Endometrial Cancer. A Gynecologic Oncology Group Study https://pubmed.ncbi.nlm.nih.gov/3652025/

Integrated Genomic Characterization of Endometrial Carcinoma https://pubmed.ncbi.nlm.nih.gov/23636398/

AXL Inhibition Improves the Therapeutic Efficacy of Trastuzumab in High-Risk Endometrial Cancer https://pubmed.ncbi.nlm.nih.gov/41270342/

Patient-Derived Xenograft Mouse Models: A High Fidelity Tool for Individualized Medicine https://pubmed.ncbi.nlm.nih.gov/30655732/

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