Healthy CEO Show: Dr. Joe Jacko on Longevity, Testosterone, and Taking Control of Your Health Host Jason Wright interviews Dr. Joe Jacko about regenerative medicine, longevity, and his critique of modern “sick care.” Jacko recounts his path from internal and sports medicine into men’s health and a concierge-style practice focused on lifestyle, hormone replacement, and comprehensive testing, arguing medical training and care are shaped by pharmaceutical funding, insurance limits, and hospital employment. They discuss testosterone therapy (targeting symptom improvement and upper-third reference ranges), common low-testosterone symptoms, and why standard primary-care labs often omit testosterone. Jacko outlines how fee-for-service restricts time and testing, contrasts it with integrated models like We Are The Armory, and explains his book, influenced by COVID-era concerns about research presentation and industry influence. Practical takeaways include prioritizing nutrition, strength training, sleep, stress management, learning, and purpose; using GLP-1s only with strength training and diet support; fasting/sauna habits; and exploring broader functional testing while avoiding overreacting to isolated abnormal results. 00:00 Show Opening 00:26 Meet Dr Joe Jocko 01:40 From Sports to Longevity 03:12 Testosterone Replacement Basics 05:06 Symptoms Over Lab Ranges 06:58 Why Primary Care Misses It 09:59 Sick Care System Origins 12:21 Fee for Service Pressures 14:31 Holistic Concierge Model 19:19 Writing Bamboozled Duped 22:53 Building Patient Agency 25:32 Natural Testosterone Boosters 28:05 Cardio Only Wakeup Call 28:41 Resistance Training For Longevity 30:41 GLP One Muscle Loss Risks 32:37 Longevity First Principles 34:48 Daily Habits Fasting Sauna 37:00 Mindset Hacks For Movement 40:00 Protein Keto And Meal Timing 41:43 Fasting As Calorie Restriction 45:29 Healthspan Thesis And Advocacy 47:52 Labs Gut Health And Testing 49:55 Where To Find Dr Jacko 50:48 Medical Disclaimer Closing

Dr. Jerry Mixon on Longevity Medicine: Hormones, Body Fat, Muscle, and Senescent Cells Dr. Jerry Mixon describes “longevity medicine” as treating aging—the progressive loss of capacity—as a medical problem focused on healthspan, not vanity. He shares that at 78 he has maintained a global hormone balance targeted to a healthy 25-year-old range for 31 years, enabling significant strength and endurance gains compared with age 50, and argues more older men should live energetic lives. Mixon emphasizes reducing excess body fat as a priority because fat acts as an inflammatory gland linked to chronic disease, while muscle acts as a healing gland producing beneficial proteins; he advocates building muscle and managing blood sugar/insulin resistance. He explains mitochondrial fragility, senescent “zombie” cells, and immune-system decline, discusses using senolytics such as dasatinib plus quercetin, and describes developing testing to measure senescent T-cell load. The conversation also covers clinic protocols, lifestyle micro-bursts of exercise, family priorities, and aligning healthcare incentives toward prevention. 00:00 Rewriting Old Age 01:46 Longevity Medicine Defined 03:24 Aging as Disease 05:05 How We Peak and Decline 06:15 What Aging Really Is 08:24 From 50 to 78 11:38 Mindset and Metrics 14:52 Start With Getting Lean 17:13 Fat vs Muscle Signals 18:56 Hormones Back to 25 20:26 Testosterone Myths 24:07 Risks and Screening 25:54 Inside the Clinic Process 29:00 Fat Inflammation Cascade 33:20 Insulin Resistance Explained 36:32 GLP-1s and Muscle 37:45 Mitochondria 101 41:14 Senescent Cell Zombies 42:41 Autophagy and Immune Cleanup 44:31 Immune System Senescence 46:10 Hormones and Senescent Load 48:54 Clearing Senescent Cells 50:33 Lifestyle Levers Exercise 53:21 Senolytics and Measuring SASP 56:54 Testing Immune Senescence 58:29 COVID and Aging Immunity 01:01:17 Personal Results and Routine 01:08:26 Family Legacy and Purpose 01:12:54 Reforming Healthcare Incentives 01:19:42 Wrap Up and Disclaimer

Jason interviews Dr. Nyan Patel about 26 years of research on peptides and glutathione, which Patel describes as a “worker bee” peptide that does work rather than signaling. Patel explains why oral, liposomal, and even IV glutathione fail to reliably reach cells, and how he developed a topical, polysaccharide-based delivery method that transfers cell-to-cell and uses mucosal routes, with skin as the most practical. They discuss glutathione decline starting around ages 30–35, lifestyle and environmental depleters (alcohol, smoke, pollutants, detergents), and Patel’s view that boosting levels can improve health span. The conversation transitions to Patel’s new skincare products, including GHK copper tripeptide, vitamin C “citrine,” and simplified serums/creams designed for absorption, plus practical advice on hydration and sleep.

00:00 Peptides Then and Now

00:47 Glutathione and Skincare Tease

02:22 Premium Packaging and Glass

04:27 Why Delivery and Absorption Matter

06:08 Peptides vs Worker Bees

12:19 Cracking Topical Glutathione

15:05 Why Oral and IV Fall Short

19:08 Polysaccharide Transport Breakthrough

22:08 Pandemic Wake Up Call

25:16 Glutathione Decline With Age

35:38 Aging Skin and Copper Peptides

37:29 What Is GHK Copper

37:49 Plasma to GHK Copper

38:48 Dirty Plasma Aging

40:42 Creating Copper Peptide

41:54 Award and Skin Scan

47:28 Simple Skincare System

49:01 Serums and Creams

52:15 Glutathione Dosing

54:20 Retinol vs DMAE

57:06 Water and Sleep Basics

59:55 Hair and Gray Claims

01:02:33 Wrap Up and Disclaimer